OTS186935 hydrochloride

OTS186935 盐酸盐

OTS186935 hydrochloride

O658722-5mg

5mg

≥99%

2-8°C储存,干燥

冰袋运输

OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC 50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochlori Appearance:Solid IC50& Target:IC50: 6.49 nM (SUV39H2) In Vitro:OTS186935 hydrochloride inhibits A549 cell growth with an IC 50 of 0.67 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo:OTS186935 hydrochloride (10mg/kg or 25mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models. MCE has not independently confirmed the accuracy of these methods. They are Biological Activity:OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC 50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochlori

C25H26ClN5O2.8/5HCl

522.31 g/mol

COC1=C(Cl)C=C(C2=CN3C=CC(N4C[C@@H](NCC5=CC=NC=C5)CC4)=CC3=N2)C(OC)=C1.[H]Cl.[8/5]

H2O : 50 mg/mL (95.73 mM; Need ultrasonic) DMSO : 25 mg/mL (47.86 mM; Need ultrasonic)