胃蛋白酶抑制剂

抑肽素 | 胃酶抑素 A

EX-A4027 | MLS000069747 | PEPSTATIN [INN] | 4er2 | AC-8820 | KBioGR_000340 | MLS006010748 | NCGC00161670-06 | Procidin S 735A | Q7166509 | UNII-U56LDN9FFT | UPCMLD-DP141:002 | WLN: QR BQ DQ EV3 | (3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-methyl-4-[

P113168-100mg

100mg

Moligand™

≥75%(HPLC)

Can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. For this application, the working concentration is typically between 1-10 μM.An inhibitor of HIV-1 and aspartic proteases. Pepstatin A inhibits the aspartic proteases cathepsin D, pepsin, and renin. Additionally, it suppresses p53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ. Can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. For this application, the working concentration is typically between 1-10 μM. An inhibitor of HIV-1 and aspartic proteases. Pepstatin A inhibits the aspartic proteases cathepsin D, pepsin, and renin. Additionally, it suppresses p53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ.

Pepstatin A 是一种酸性蛋白酶（天冬氨肽酶）抑制剂。它能与胃蛋白酶、肾素、凝血酶 D、牛糜蛋白酶和蛋白酶 B（黑曲霉）等蛋白酶形成 1:1 的复合物。该抑制剂具有高度选择性，不会抑制硫醇蛋白酶、中性蛋白酶或丝氨酸蛋白酶。Pepstatin A 还能抑制溶解的 γ-secretase 和逆转录病毒蛋白酶。与胃蛋白酶、肾素、凝血酶 D 和 E 形成 1:1 复合物，可抑制溶解的γ-分泌酶和逆转录病毒蛋白酶。体内活性。

2201362

Isovaleryl-Val-Val-Sta-Ala-Sta