Pomalidomide抑制LPS诱导的TNF-alpha释放， IC50为13 nM。 应用： 泊马度胺已被用于：处理BV173 细胞以研究蛋白质水解靶向嵌合体 (PROTAC) 化合物 JQ1-CRBN 在诱导特异性 I 类主要组织相容性复合体 (MHC-I) 肽中的作用 ；用于细胞凋亡研究和细胞内钙分析；作为胎儿血红蛋白 (HbF) 试剂用于研究 对& #946;-地中海贫血/变异血红蛋白 E (HbE) 红系祖细胞中胎儿血红蛋白表达水平与UNC0638 的累加效应。 Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM. Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog. An inhibitor of LPS-induced TNFαrelease. Application： Pomalidomide has been used:to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides；for apoptosis studies and intracellular calcium analysis；as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells.