在钯催化剂存在下与 1-溴-1-炔反应生成具有生物活性的炔烯醇内酯。通过双乙炔的关环复分解反应合成细胞毒性大环内酯。 4-Pentynoic acid is used in a synthesis of a cytotoxic macrolide by ring-closing metathesis of a bis acetylene.: Reaction with 1-bromo-1-alkynes in the presence of a Pd catalyst yields biologically active ynenol lactones. Reaction with 1-bromo-1-alkynes in the presence of a Pd catalyst yields biologically active ynenol lactones. 1