PSB-12062

小分子

Oprea1_008733 | PSB-12062 | N-(p-Methylphenylsulfonyl)phenoxazineN-(p-Methylphenylsulfonyl)phenoxazine | 10-tosyl-10H-phenoxazine | GTPL9542 | AKOS027422597 | 10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]- | EX-A7266 | 10-(4-methylphenyl)sulfonylphenoxaz

PSB-12062

P646739-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

PSB-12062 is a potent and selective P2X4 antagonist with an IC 50 of 1.38 μM for human P2X4. In Vitro PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4)

PSB-12062 是一种强效的选择性 P2X4 拮抗剂，对人类 P2X4 的 IC 50 为 1.38 μM。

55476-47-6

C19H15NO3S

337.39 g/mol

2320735

CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3OC4=CC=CC=C42

10-(4-methylphenyl)sulfonylphenoxazine

1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3

DHZNMEIBMACSFH-UHFFFAOYSA-N

CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3OC4=CC=CC=C42

2320735

DMSO : 25 mg/mL (74.10 mM; Need ultrasonic)

0

4

2

337.077 Da

337.077 Da

55.000 Ų

24

0

513.000

0

1

4.200

NONHforallmodesoftransport