p-Ethynylphenylalanine hydrochloride

对乙炔基苯丙氨酸盐酸盐

p-Ethynylphenylalanine hydrochloride

P647248-50mg

50mg

≥99%

2-8°C储存,干燥

冰袋运输

p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM In Vitro p-Ethynylphenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin. p-Ethynylphenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors (5-HT 1 , 5-HT 2 , 5-HT 4 , 5-HT 5 , 5-HT 6 , and 5-HT 7 ). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue . p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (200 g) Dosage: 30 mg/kg Administration: Intraperitoneal injection Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain. Form:Solid IC50& Target:Ki: 32.6 μM (TPH)

对乙炔基苯丙氨酸盐酸盐（4-乙炔基-L-苯丙氨酸盐酸盐）是色氨酸羟化酶（TPH）的一种强效、选择性、可逆和竞争性抑制剂，其 K i 为 32.6 μM。

188640-63-3

C11H12ClNO2

225.67 g/mol

127264445

C#CC1=CC=C(C=C1)C[C@@H](C(=O)O)N.Cl

C#CC1=CC=C(C=C1)C[C@@H](C(=O)O)N.Cl

127264445

DMSO : 50 mg/mL (221.56 mM; ultrasonic and warming and heat to 60°C) H2O : 12.5 mg/mL (55.39 mM; Need ultrasonic)

3

3

4

225.056 Da

225.056 Da

63.300 Ų

15

0

245

0

2