PIK-108 is a non-ATP competitive, allosteric p110β / p110δ selective inhibitor. In Vitro PIK-108 (0.1-10 μM; 1 hour) blocks phosphorylation of PKB/Akt. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Glioma cell lines expressing wild-type PTEN Concentration: 0.1, 0.5, 1, 4, and 10 μM Incubation Time: 1 hour Result: Showed variable inhibition of PKB/Akt phosphorylation but exhibited a trend toward reducing PKB/Akt phosphorylation more effectively in mutant PTEN-expressing cell lines than in wild-type PTEN-expressing cell lines. Form:Solid