Peldesine dihydrochloride

盐酸哌地辛

Peldesine dihydrochloride

P651120-5mg

5mg

≥99%

2-8°C储存,干燥

冰袋运输

Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC 50 s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP , respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC 50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research In Vitro Peldesine (BCX 34; 0-50 µM; 72 hours; Jurkat cells) could inhibit the T-cell proliferation completely at a concentration of less than 10 μM, in the presence of dGuo (10 μM). In contrast, the B-cell proliferation is not affected by Peldesine. Peldesine (BCX 34) suppresses T-cell immune reaction in an IL-2-independent manner, and this means that Peldesine might affect a late phase rather than an early stage in T-cell activation. Peldesine also, in the presence but not in the absence of deoxyguanosine, inhibits human leukemia CCRF-CEM T-cell proliferation with an IC 50 of 0.57 μM but not rat or mouse T-cell proliferation up to 30 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Jurkat cells Concentration: 0-50 µM Incubation Time: 72 hours Result: In the presence of 10 µM dCuo, had a complete inhibitory effect for T-cell lines. Form:Solid IC50& Target:IC50: 36 nM (Human RBC PNP), 5 nM (Rat RBC PNP), 32 nM (Mouse RBC PNP), and 800 nM (Human T-cell proliferation),Ki: 23 nM (Human RBC PNP),HIV

Peldesine (BCX 34) 二盐酸盐是一种强效、竞争性、可逆和口服活性嘌呤核苷磷酸化酶（PNP）抑制剂，对人、大鼠和小鼠红细胞（RBC）PNP 的 IC 50 s 分别为 36 nM、5 nM 和 32 nM。Peldesine d

2772702-10-8

C12H13Cl2N5O

314.17 g/mol

Cl[H].O=C1C(NC=C2CC3=CC=CN=C3)=C2N=C(N)N1.Cl[H]

DMSO : 200 mg/mL (636.60 mM; Need ultrasonic) H2O : 33.33 mg/mL (106.09 mM; Need ultrasonic)