PF-2771

PF-2771

P651294-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor, inhibiting CENP-E motor activity with an IC 50 of 16.1 nM; PF-2771 is used as an anticancer agent. In Vitro PF-2771 is a potent and selective CENP-E inhibitor, inhibiting CENP-E motor activity with an IC 50 of 16.1 nM. PF-2771 shows no inhibitory effect on the ATPase activities of highly related kinesins (0% inhibition of Eg5/KSP, chromokinesin, and MCAK at both 1 or 10 μM PF-2771). PF-2771 exhibits inactive activity against 74 protein kinases (all 5 μM). PF-2771 (100 nM) reusults in a chromosomal congression defect in MDA-MB-468 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo PF-2771 (100 mg/kg, every day i.p.) potently inhibits CENP-E motor function, and causes tumor regression in SCID mice bearing AA1077 mammary tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

PF-2771 是一种强效、选择性的中心粒蛋白 E（CENP-E）抑制剂，可抑制 CENP-E 的运动活性，IC50 为 16.1 nM；PF-2771 可用作抗癌剂。

2070009-55-9

C29H36ClN5O4

554.08 g/mol

ClC1=CC(C(N[C@@H](CC2=CC=C(C3=CN(C)C(C(C)=O)=N3)C=C2)CNC(CN(C)C)=O)=O)=CC=C1OC(C)C

DMSO : ≥ 32 mg/mL (57.75 mM)