PF-04856264

小分子

PF-04856264

P654480-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC 50 s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect In Vivo PF-04856264 (3-30 mg/kg; i.p.) reverses OD1-induced pain behaviors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 weeks adult male C57BL/6J mice (OD1-induced spontaneous pain model)Dosage: 3, 30 mg/kg Administration: I.p. Result: Significantly reduced spontaneous pain behaviors in mice. IC50& Target:IC50: 28 (human Nav1.7), 131 nM (mouse Nav1.7), 19 nM (cynomolgus monkey Nav1.7), 42 nM (dog Nav1.7)

PF-04856264 是一种强效的选择性 Nav1.7 抑制剂，对人、小鼠、猴和狗 Nav1.7 的 IC 50 s 分别为 28、131、19 和 42 nM。PF-04856264 对大鼠 Nav1.7 通道的效力较低。PF-04856264 具有镇痛作用

1235397-05-3(DMSO)

C20H15N5O3S2

437.49 g/mol

CN1C(=CC=N1)C2=CC=CC=C2OC3=C(C=C(C=C3)S(=O)(=O)NC4=NC=CS4)C#N