Pyr6

Pyr6

P654814-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).IC50 value: 0.49 uM Target: TRPC3 inhibitorPyr6 is a selective SOCE inhibitor (Yonetoku et al., 2008; Sweeney et al., 2009), Pyr6 displayed 37-fold (1.58 OM) higher potency for RBL SOCE than for TRPC3 ROCE, with an IC50 comparable to that of Pyr2 and Pyr3. Pyr6 at 3 uM diminished TRPC3 currents to only 52%. Consistent with inhibition of Orai channel activity Pyr2, Pyr3 or Pyr6 substantially inhibited typical Orai downstream signalling events in RBL mast cells (NFAT activation and degranulation) activated by passive store depletion.

Pyr6 是一种 TRPC3 选择性抑制剂，其 IC50 值为 0.49 uM（抑制硫糖金耗竭的原生 RBL-2H3 细胞中的 Ca2+ 流入）：Pyr6 是一种选择性 SOCE 抑制剂（Yonetoku 等人，2008 年；Sweeney 等人，2009 年）。

245747-08-4(DMSO)

C17H9F7N4O

418.27 g/mol

C1=CC(=CC=C1NC(=O)C2=C(C=NC=C2)F)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F