POMHEX

聚甲基丙烯酸甲酯

POMHEX

P655282-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2 -specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor. In Vitro POMHEX (78 nM, 8h) minimally impacts ENO1-WT glioma cells but profoundly affected ENO1-deleted cells. ?\nPOMHEX (0-720 nM) selectively induces energy stress, inhibits proliferation and triggers apoptosis in ENO1-deleted glioma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: ENO1-deleted (D423, red), ENO1-isogenically rescued (D423 ENO1, blue) and ENO1-WT (LN319, grey) cells. Concentration: 78 nM. Incubation Time: 8 h. Result: Down-regulated cell density. In Vivo POMHEX (i.v., ip) injections are consistently tolerated without haemolytic anaemia at doses of up to 10 mg per kg (body weight) per day. POMHEX (i.v., 35 mg/kg) results in lethargy that prompted veterinarians to perform euthanasia . ?\nPOMHEX is rapidly hydrolysed to HemiPOMHEX in mouse plasma ex vivo, with a half-life of approximately 30 s, the half-life in human blood ex vivo was about 9min . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

POMHEX是HEX的外消旋混合物和细胞渗透性新戊酰氧基甲基（POM）原药，是一种强效的ENO2烯醇化酶特异性抑制剂。POMHEX 对体外ENO1缺失细胞具有低纳摩尔效力，并能根除ENO1缺失细胞。

2004714-34-3(DMSO)

C17H30NO9P

423.40 g/mol

O=P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)C1C(N(O)CCC1)=O