PF-6683324

小分子

PF-6683324

P655549-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC 50 s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA , TrkB and TrkC , respectively Anti-hyperalgesic effect In Vitro PF-6683324 (Trk-IN-4) (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC 50 >5 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:TrkA 1.9 nM (IC 50 , in cell-based assays) TrkB 2.6 nM (IC 50 , in cell-based assays) TrkC 1.1 nM (IC 50 , in cell-based assays)

在基于细胞的试验中，PF-6683324（Trk-IN-4）是一种强效的泛 Trk 抑制剂，对 TrkA、TrkB 和 TrkC 的 IC 50 s 分别为 1.9 nM、2.6 nM 和 1.1 nM。抗镇痛作用。

1799788-94-5(DMSO)

C24H23F4N5O4

521.46 g/mol

CN1C=C(N=C1)C2=CC(=C(N=C2)OC3CCN(CC3F)C(=O)CC4=CC=C(C=C4)OC(F)(F)F)C(=O)N

酪氨酸激酶