PF-03463275

PF-03463275

P655859-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a K i of 11.6 nM. PF-03463275 has the potential for Schizophrenia research. In Vivo PF-03463275 (1-10 mg/kg; s.c.) attenuates oscillatory potentials (OPs). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley ratsDosage: 1, 3 and 10 mg/kg Administration: S.c. Result: A dose-dependent reduction in the amplitude of oscillatory potentials (OPs) elicited from the dark-adapted rats.

PF-03463275 是一种中枢渗透性、口服型、选择性和竞争性 GlyT1（甘氨酸转运体-1）可逆抑制剂，其 K i 为 11.6 nM。PF-03463275 具有研究精神分裂症的潜力。

1173239-39-8(DMSO)

C19H22ClFN4O

376.86 g/mol

CN1CC2C(C1)C2CN(CC3=CC(=C(C=C3)F)Cl)C(=O)C4=CN(C=N4)C