PHT-7.3

未知

PHT-7.3

P655934-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain ( K d =4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity In Vivo PHT-7.3 (200 mg/kg; i.p.; daily; for 20 days) exhibits cytostatic antitumor activity in the mut-KRas(G12S) A549 xenograft and mut-KRasG12V H441 xenograft . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female NOD-SCID mice (mut-KRas A549 NSCLC xenografts, mut-KRas H441 NSCLC xenografts) Dosage: 200 mg/kg Administration: Intraperitoneal injection, daily, for 20 days Result: Exhibited cytostatic antitumor activity in the mut-KRas(G12S) A549 xenograft and mut-KRasG12V H441 xenograft . IC50& Target:Cnk1 PH-domain

PHT-7.3 是一种 Ras 1（Cnk1）pleckstrin homology（PH）结构域连接器增强激酶抑制剂的选择性抑制剂（K d =4.7 μM）。PHT-7.3 可抑制突变型 KRas 癌细胞和肿瘤的生长和信号传导，但不能抑制野生型 KRas 癌细胞和肿瘤的生长和信号传导。PHT-7.3 具有抗肿瘤作用。

1614225-93-2(DMSO)

C24H23N3O3S

433.52 g/mol

CC1=CC=C(C=C1)C2=CSC(=N2)CN3C(=O)C4=CC=CC=C4C(=N3)CC5OCCCO5