PSB-12379

PSB-12379

P655974-1ml

1ml

10mM in Water

-80℃储存

超低温冰袋运输

PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase ( CD73 ) inhibitor with K i s of 9.03 nM (rat) and 2.21 nM (human) In Vitro Metabolism : Only a small percentage ( 77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)

PSB-12379 是一种核苷酸类似物，是一种强效的外-5'-核苷酸酶（CD73）抑制剂，其 K i s 为 9.03 nM（大鼠）和 2.21 nM（人类）。

1802226-78-3(Water)

C18H23N5O9P2

515.35 g/mol

C1=CC=C(C=C1)CNC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)COP(=O)(CP(=O)(O)O)O)O)O