PLX5622 hemifumarate

PLX5622 半富马酸盐

PLX5622 hemifumarate

P658668-5mg

5mg

≥99%

2-8°C储存,干燥

冰袋运输

PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor ( IC 50 =0.016 µM; K i =5.9 nM). PLX5622 hemifumarate allows for extended and specific microglial elimination, preceding and during pathology development. PLX5622 Appearance:Solid IC50& Target:CSF1R In Vitro:PLX5622 (1-20 μM; 3 days) hemifumarate effectively depletes microglia without affecting oligodendrocytes or astrocytes in cerebellar slices. PLX5622 (4 μM; 3 days) hemifumarate causes a 30-40% reduction in NG2+ or PDGFRα+ cells, and this increased to 90-9 In Vivo:Pharmacodynamics of PLX5622 hemifumarate in preclinical studies PLX5622 (1200 ppm; chow; for 3 weeks or 3 days; adult C57/Bl6 wild type mice) hemifumarate leads to around 80% of microglia lost after 3 days of treatment and a 99% microglia loss after 3 wee Biological Activity:PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor ( IC 50 =0.016 µM; K i =5.9 nM). PLX5622 hemifumarate allows for extended and specific microglial elimination, preceding and during pathology development. PLX5622

C23H21F2N5O3

453.45 g/mol

COC1=NC=C(F)C=C1CNC2=NC(F)=C(CC3=CNC4=NC=C(C)C=C43)C=C2.O=C(O)/C=C/C(O)=O.[1/2]

DMSO : 100 mg/mL (220.53 mM; Need ultrasonic)