PAD2-IN-1 hydrochloride

PAD2-IN-1 盐酸盐

PAD2-IN-1 hydrochloride

P658847-5mg

5mg

≥99%

2-8°C储存,避光,干燥

冰袋运输

PAD2-IN-1 hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold). Appearance:Solid IC50& Target:Protein Arginine Deiminase 2 (PAD2) In Vitro:In the target engagement assay, the EC 50 of PAD2-IN-1 (compound 32a) hydrochloride is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells. PAD2-IN-1 (compound 32a; 1-25 μM) hydrochlori Biological Activity:AFM32a (PAD2-IN-1) hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).

C25H30ClFN6O3

517 g/mol

O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N.[H]Cl

DMSO : 100 mg/mL (193.42 mM; Need ultrasonic)