PDE10A-IN-2 hydrochloride

PDE10A-IN-2盐酸盐

PDE10A-IN-2 hydrochloride

P658867-5mg

5mg

≥98%

2-8°C储存,干燥

冰袋运输

PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC 50 of 2.8 nM. PDE10A-IN-2 hydrochloride shows selectivity of >3500-fold against other PDE subtypes. PDE10A-IN-2 hydrochloride can Appearance:Solid IC50& Target:PDE10A 2.8 nM (IC 50 ) In Vivo:PDE10A-IN-2 hydrochloride (compound 14 3HCL; 2.5mg/kg; oral administration; daily; for 3 weeks) treatment decreases the typical symptoms of PAH in rats. In Sprague-Dawley rats, the pharmacokinetic study of PDE10A-IN-2 hydrochloride (compound 14 3HCL Biological Activity:PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC 50 of 2.8 nM. PDE10A-IN-2 hydrochloride shows selectivity of >3500-fold against other PDE subtypes. PDE10A-IN-2 hydrochloride can

C33H38Cl3N5O

627.05 g/mol

CN1CCN(CCCOC2=CC(N3C(/C=C/C4=C5N=CC=CC5=CC=C4)=NC6=CC(C)=CC=C36)=CC=C2)CC1.[H]Cl.[H]Cl.[H]Cl

DMSO : 100 mg/mL (159.48 mM; Need ultrasonic)