PD-1/PD-L1-IN-9 hydrochloride

PD-1/PD-L1-IN-9盐酸盐

PD-1/PD-L1-IN-9 hydrochloride

P659048-5mg

5mg

≥99%

2-8°C储存,干燥

冰袋运输

PD-1/PD-L1-IN-9 hydrochloride is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC 50 of 3.8 nM. PD-1/PD-L1-IN-9 hydrochloride can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 hydrochloride also exh Appearance:Solid In Vitro:PD-1/PD-L1-IN-9 hydrochloride (compound 24) (46.9-1500 nM; pretreated for 2 h) dose-dependently significantly activates the antitumor immunity of peripheral blood mononuclear cells (PBMCs) to MDB-MB 231 cells, with an EC 50 of ∼100 nM. MCE has not in In Vivo:PD-1/PD-L1-IN-9 hydrochloride (compound 24) (40-80mg/kg; p.o.; once a day for 2 weeks) inhibits tumor growth in a dose-dependent manner and does not cause any body weight loss or mortality of mice. PD-1/PD-L1-IN-9 hydrochloride (3mg/kg; i.v.; singl Biological Activity:PD-1/PD-L1-IN-9 hydrochloride is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC 50 of 3.8 nM. PD-1/PD-L1-IN-9 hydrochloride can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 hydrochloride also exh

C22H25ClN2O2

384.9 g/mol

CC1=C(C=CC=C1C2=CC=CC=C2)C3=NC(OC)=C(C=C3)CNCCO.[H]Cl

DMSO : 125 mg/mL (324.76 mM; Need ultrasonic)