PMX 205 Trifluoroacetate

PMX 205 三氟乙酸盐

PMX 205 Trifluoroacetate

P659194-5mg

5mg

≥99%

-20°C储存,干燥

超低温冰袋运输

PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist. Appearance:Solid IC50& Target:C5aR In Vitro:A complement activation product, C5a, is known to recruit and activate microglia and astrocytes in vitro by activation of a G protein-coupled cell-surface C5aR. In the MTT assay, in 24 h plate, it shows that all groups are significant when compared with n In Vivo:PMX 205 (PMX205) is an orally active, selective C5aR antagonist. Animals treated with PMX 205 (1mg/kg/day, oral) display a significant extension of survival time and a reduction in end-stage motor scores, as compared with vehicle-treated rats. PMX 205-tr Biological Activity:PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.

C47H63F3N10O8

953.06 g/mol

OC(C(F)(F)F)=O.O=C([C@H](NC([C@@]1([H])N(CCC1)C([C@](NC(CCC2=CC=CC=C2)=O)([H])CCCNC([C@H](CCCNC(N)=N)NC3=O)=O)=O)=O)CC4CCCCC4)N[C@@]3([H])CC5=CNC6=CC=CC=C56

DMSO : ≥ 100 mg/mL (104.93 mM) H2O : ＜ 0.1 mg/mL (ultrasonic) (insoluble)