PROTAC BRD4 Degrader-8

PROTAC BRD4 降解剂-8

PROTAC BRD4 Degrader-8

P659242-5mg

5mg

≥98%

避光,-20°C储存

超低温冰袋运输

PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 , with IC 50 s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2 , respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer Appearance:Solid IC50& Target:IC50: 1.1 nM (BRD4 BD1), 1.4 nM (BRD4 BD2) In Vitro:PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC 50 of 28 nM. PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC 50 of 11 nM. PROTAC BRD4 Deg Biological Activity:PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 , with IC 50 s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2 , respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer

C53H61F2N9O11S2

1102.23 g/mol

O[C@H](C[C@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)CN1C([C@@H](NC(COCCOCCOCCNC(C4=CC(N(C5=NC=C(F)C=C5F)CC6=CNC7=C6C8=CN(C)C7=O)=C8C=C4CS(=O)(C)=O)=O)=O)C(C)(C)C)=O

DMSO : 90 mg/mL (81.65 mM; Need ultrasonic)