PDE4B-IN-3

PDE4B-IN-3

P659387-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

PDE4B-IN-3 is a potent PDE4B inhibitor with an IC 50 of 0.94 μM. PDE4B-IN-3 has anti-inflammatory activities. Appearance:Solid IC50& Target:PDE4B 0.94 μM (IC 50 ) In Vitro:PDE4B-IN-3 (compound f4) has good inhibitory activity on the production of NO, TNF-α and IL-1β with IC 50 values of 20.40 μM, 23.48 μM, and 18.98 μM in RAW264.7 cells. PDE4B-IN-3 could also inhibit the expression of iNOS and COX-2 in RAW264.7 cells. In Vivo:In vivo studies shows that PDE4B-IN-3 (compound f4; 10-30mg/kg) could improve the degree of foot swelling and knee joint pathology in adjuvant-induced arthritic rats and decrease the levels of serum inflammatory factors TNF-α and IL-1β in a dose-dependen Biological Activity:PDE4B-IN-3 is a potent PDE4B inhibitor with an IC 50 of 0.94 μM. PDE4B-IN-3 has anti-inflammatory activities.

C30H35N3O4S2

565.75 g/mol

CC(C1=CC(C(C)C)=C(C(C(C)C)=C1)S(=O)(NC2=CC(NS(=O)(C3=CC=CC4=CC=CN=C43)=O)=CC=C2)=O)C

DMSO : 50 mg/mL (88.38 mM; Need ultrasonic)