PROTAC-O4I2

PROTAC-O4I2

P661683-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 ( SF3B1 ). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC 50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells. IC50& Target:Cereblon In Vitro:PROTAC-O4I2 introduces Thalidomide to ubiquitin E3 ligase cereblon (CRBN), which selectively degrades SF3B1 and inhibits tumor growth in cells. PROTAC-O4I2 degrades and inhibits SF3B1 in K562 cells. PROTAC-O4I2 exhibits anti-proliferation effects In Vivo:PROTAC-O4I2 (10 μM) significantly increases survival by interference with the maintenance and proliferation of tumor in a Drosophila intestinal tumor model. MCE has not independently confirmed the accuracy of these methods. They are for reference onl Biological Activity:PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 ( SF3B1 ). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC 50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells.

C29H29ClN6O5S

609.1 g/mol

O=C(NCCCCCCNC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O)C4=CSC(NC5=CC=C(C=C5)Cl)=N4