PXS-5153A monohydrochloride

PXS-5153A单盐酸盐

PXS-5153A monohydrochloride

P661690-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC 50 of In Vitro:PXS-5153A exhibits an IC 50 of 40-fold selective for LOXL2 over both LOX and LOXL1 and >700-fold selective over other rel In Vivo:As expected, rhLOXL2 dose-dependently induce oxidation of collagen with PXS-5153A dose-dependently impeding collagen oxidation. Therapeutic treatment of PXS-5153A substantially reduces immature crosslink formation compared with the CCl 4 treated animals. Biological Activity:PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC 50 of

\n C20H24ClFN4O2S

438.95 g/mol

CC(N1C/C(F)=C/CN)=C(C2=CC=CC(S(N(C)C)(=O)=O)=C2)C3=C1C=CC=N3.Cl