PD0325901是一种选择性的，ATP非竞争性的MEK抑制剂，IC50为0.33 nM，对ERK1和ERK2磷酸化抑制作用比CI-1040强500倍左右An inhibitor of MEK and suppressor of ERK phosphorylation PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. An inhibitor of MEK and suppressor of ERK phosphorylation