Information PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist ofserotonin 4 receptor (5-HT4R)with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. As for rat 5-HT4S/4L/4E, the EC50 is 0.59 nM, 0.65 nM and 0.62 nM, respectively. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. Targets human 5-HT4E (Cell-free assay); human 5-HT4B (Cell-free assay); human 5-HT4D (Cell-free assay); human 5-HT4A (Cell-free assay); rat 5-HT4S (Cell-free assay) 32770,0.26 nM(EC50); 0.36 nM(EC50); 0.37 nM(EC50); 0.47 nM(EC50); 0.59 nM(EC50)