rac-CCT-250863 盐酸盐

4-[2-氨基-5-[4-[((二甲基氨基)甲基] -2-噻吩基] -3-吡啶基] -2-[[((2Z))-4,4,4-三氟-1-甲基-2 -丁烯-1-基]氧基]苯甲酰胺盐酸盐

4-[2-Amino-5-[4-[(dimethylamino)methyl]-2-thienyl]-3-pyridinyl]-2-[[(2Z)-4,4,4-trifluoro-1-methyl-2-buten-1-yl]oxy]benzamide HCl

rac-CCT-250863 HCl

R288579-10mg

10mg

≥98%(HPLC)

-20°C储存

超低温冰袋运输

(Rac)-CCT 250863 盐酸盐 是一种具有选择性和可逆性的 NEK 2 抑制剂，其 IC50 值为 0.073 µM。(Rac)-CCT 250863 能诱导细胞周期停滞并有较好的抗癌细胞 (Pomalidomide 敏感/耐药) 增殖活性。(Rac)-CCT 250863 与 Pomalidomide 联用能诱导细胞凋亡，可用于联合抗癌的研究。 rac-CCT-250863 HCl is a selective and reversible inhibitor of NEK 2. rac-CCT-250863 HCl induces cell cycle arrest and has good anti-proliferative activity against cancer cells. rac-CCT-250863 HCl can be used in combination with Pomalidomide to induce apoptosis and can be used in combined anti-cancer studies. Product Describtion: Potent Nek2 inhibitor

强大的Nek2抑制剂（IC50 = 73 nM）。与PLK1，MPS1，Cdk2和Aurora A相比，Nek2具有选择性。

1364269-06-6(Free base)

C24H25F3N4O2S(Free base)

490.54(Free base) g/mol

溶于1eq. HCl, 最高浓度 (mg/mL): 49.05, 最高浓度(mM): 100；溶于DMSO, 最高浓度 (mg/mL): 49.05, 最高浓度(mM): 100