Rp-腺苷3'，5'-环一硫代磷酸钠盐（Rp-cAMP）是一种膜通透性化合物，已证明是PKA抑制剂（依赖cAMP）。该化合物具有抑制dbcAMP和Sp-cAMPS（sc -201571）诱导的小鼠骨吸收刺激的能力。此外，由于其对cAMP的作用，Rp-cAMP还可以抑制cAMP介导的某些细胞的生长。注意到的PKA激活抑制的其他作用包括从饲喂大鼠分离的肝细胞中胰高血糖素诱导的糖原分解的减少。 Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt (Rp-cAMP), a membrane permeable compound, is shown to be an an inhibitor of PKA (cAMP-dependent). This compound displays a capacity to inhibit dbcAMP- and Sp-cAMPS (sc -201571)-induced stimulation of bone resorption in mice. Furthermore, due to its effects on cAMP, Rp-cAMP can also inhibit cAMP mediated cell growth of certain cells. Other effects of PKA activation inhibition noted include a decrease in Glukagon-induced glycogenolysis in hepatocytes isolated from fed rats.