RO0270608

小分子

RO0270608

R646217-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity In Vitro RO0270608 inhibits α4/β7 mediated cell adhesion with an IC50 of 33 nM. In a human T-cell VCAM/anti CD3 costimulation assay RO0270608 causes a pronounced inhibition of T-cell proliferation (IC 50 =30 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulationMCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:α4β1 α4β7

RO0270608是R411的活性代谢物，是一种双重α4β1-α4β7（α4β1/α4β7）整合素拮抗剂。抗炎活性。

220846-33-3

C24H19Cl3N2O4

505.78 g/mol

16727128

CC1=C(C(=CC=C1)Cl)C(=O)N[C@@H](CC2=CC=C(C=C2)NC(=O)C3=C(C=CC=C3Cl)Cl)C(=O)O

(2S)-2-[(2-chloro-6-methylbenzoyl)amino]-3-[4-[(2,6-dichlorobenzoyl)amino]phenyl]propanoic acid

1S/C24H19Cl3N2O4/c1-13-4-2-5-16(25)20(13)22(30)29-19(24(32)33)12-14-8-10-15(11-9-14)28-23(31)21-17(26)6-3-7-18(21)27/h2-11,19H,12H2,1H3,(H,28,31)(H,29,30)(H,32,33)/t19-/m0/s1

JTVWJXUGGJTGDA-IBGZPJMESA-N

CC1=C(C(=CC=C1)Cl)C(=O)NC(CC2=CC=C(C=C2)NC(=O)C3=C(C=CC=C3Cl)Cl)C(=O)O

16727128

DMSO : 12.5 mg/mL (24.71 mM; ultrasonic and warming and heat to 60°C)

3

4

7

504.041 Da

504.041 Da

95.500 Ų

33

0

691.000

0

1

5.900