6RK73

6RK73

R646227-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC 50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC 50 =236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer In Vitro 6RK73 (5 μM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells. ?\n6RK73(5 μM; 24-48 hours) results migration significantly slower than the DMSO control group in MDA-MB-436 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MDA-MB-436 cells Concentration: 5 µM Incubation Time: 24, 48 hours Result: Migrated significantly slower than the DMSO control group Western Blot AnalysisCell Line: MDA-MB-436 cells Concentration: 5 µM Incubation Time: 1, 2, 3 hours Result: Displayed strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels. In Vivo 6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.23 µM (UCHL1), 236 µM (UCHL3)

6RK73 是一种共价不可逆特异性 UCHL1 抑制剂，其 IC 50 为 0.23 µM。6RK73 对 UCHL3 几乎没有抑制作用（IC 50 =236 µM）。6RK73 能特异性抑制乳腺癌中 UCHL1 的活性。

1895050-66-4

C13H17N5O2S

307.37 g/mol

121248200

C1CN(C[C@H]1C(=O)NC2=NC=C(S2)N3CCOCC3)C#N

(3S)-1-cyano-N-(5-morpholin-4-yl-1,3-thiazol-2-yl)pyrrolidine-3-carboxamide

1S/C13H17N5O2S/c14-9-17-2-1-10(8-17)12(19)16-13-15-7-11(21-13)18-3-5-20-6-4-18/h7,10H,1-6,8H2,(H,15,16,19)/t10-/m0/s1

ONIHSXKWNFYNNS-JTQLQIEISA-N

C1CN(CC1C(=O)NC2=NC=C(S2)N3CCOCC3)C#N

121248200

DMSO : 125 mg/mL (406.68 mM; Need ultrasonic)