Risarestat

小分子

利沙司他

5-[3-ethoxy-4-(pentyloxy)phenyl]-2,4-thiazolidinedione | SCHEMBL1814433 | HY-16433 | CAS-79714-31-1 | Q27088451 | Risarestat | MS-24804 | 5-(3-Ethoxy-4-(pentyloxy)phenyl)-2,4-thiazolidinedione | 5-(3-ethoxy-4-pentoxyphenyl)-1,3-thiazolidine-2,4-dione | Q2

Risarestat

R647182-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications. In Vivo Risarestat inhibits the accumulation of dulcitol in a dose-dependent manner, except for the 1.0% solution which has an activity comparable to the 0.25% solution . Risarestat peaks in the corneal epithelium, stroma, endothelium and aqueous humor in 30 minutes following instillation, then gradually diminishes time-dependently over a period of 24 hours. Risarestat remains detectable in the lens up to 24 hours, with a peak concentration at 2 hours after instillation. The anterior surface area of superficial cells in the group treated with Risarestat is significantly decreases from a mean value of 881 to 728 microns 2 . Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm 2. Animals treated with Risarestat shows a significant increase in the mean blinkresponse compared to untreated galactose-fed rats and does not differ significantly from controls towards the completion of the 7 month study. Animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Risarestat (CT-112) 是一种醛糖还原酶抑制剂，用于治疗糖尿病并发症。

79714-31-1

C16H21NO4S

323.41 g/mol

133264

CCCCCOC1=C(C=C(C=C1)C2C(=O)NC(=O)S2)OCC

5-(3-ethoxy-4-pentoxyphenyl)-1,3-thiazolidine-2,4-dione

1S/C16H21NO4S/c1-3-5-6-9-21-12-8-7-11(10-13(12)20-4-2)14-15(18)17-16(19)22-14/h7-8,10,14H,3-6,9H2,1-2H3,(H,17,18,19)

CRPGRUONUFDYBG-UHFFFAOYSA-N

CCCCCOC1=C(C=C(C=C1)C2C(=O)NC(=O)S2)OCC

133264

79714-31-1

5-(3-ethoxy-4-pentyloxyphenyl)-2,4-thiazolidinedione;CT 112;CT-112;risarestat

DMSO : 105 mg/mL (324.67 mM; Need ultrasonic)

1

5

8

323.119 Da

323.119 Da

89.900 Ų

22

0

390.000

0

1

3.900