RIPK1-IN-4

小分子

RIPK1-IN-4

R648090-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC 50 s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase Form:Solid IC50& Target:IC50: 16 nM (RIP1) and 10 nM (ADP-Glo)

RIPK1-IN-4 （化合物 8）是受体互作蛋白 1（RIP1）激酶的一种强效、选择性 II 型激酶抑制剂，能与 DLG-out 非活性形式的 RIP1 结合，对 RIP1 和 ADP-Glo 激酶的 IC 50 s 分别为 16 nM 和 10 nM。

1481641-08-0

C23H23N5O2

401.46 g/mol

71816195

CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CC=CC4=C3C=CN=C4N

1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea

1S/C23H23N5O2/c1-23(2,3)19-13-20(28-30-19)27-22(29)26-15-9-7-14(8-10-15)16-5-4-6-18-17(16)11-12-25-21(18)24/h4-13H,1-3H3,(H2,24,25)(H2,26,27,28,29)

SLRYMOUSQMDJPH-UHFFFAOYSA-N

CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CC=CC4=C3C=CN=C4N

71816195

DMSO : 250 mg/mL (622.73 mM; Need ultrasonic)

3

5

4

401.185 Da

401.185 Da

106.000 Ų

30

0

587.000

0

1

4.400