Rosabulin

小分子

罗莎布林 | 罗沙布林 | STA 5312 | 3-[(4-氰基苯基)甲基]-N-(3-甲基-5-异噻唑基)-ALPHA-氧代-1-中氮茚乙酰胺

3-[(4-Cyanophenyl)methyl]-N-(3-methyl-5-isothiazolyl)-alpha-oxo-1-indolizineacetamide | 1-Indolizineacetamide, 3-((4-cyanophenyl)methyl)-N-(3-methyl-5-isothiazolyl)-alpha-oxo- | 2-[3-[(4-cyanophenyl)methyl]indolizin-1-yl]-N-(3-methyl-1,2-thiazol-5-yl)-2-o

Rosabulin

R648397-5mg

5mg

Moligand™

≥98%

-20°C储存

超低温冰袋运输

In Vitro Rosabulin (STA 5312) demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, including hematologic and solid tumor cell lines of various origins (e.g. leukemia, lymphoma, breast, colon, uterine), with IC 50 values extending down into the nanomolar range. Cell lines with multi-drug resistant (MDR) phenotypes are similarly sensitive to Rosabulin. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo When dosed orally or intravenously, Rosabulin (STA 5312) has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Rosabulin (STA 5312) 是一种有效的微管 (microtubule) 抑制剂，可抑制微管组装。Rosabulin 具有广谱抗肿瘤活性。

501948-05-6

C22H16N4O2S

400.45 g/mol

9843935

CC1=NSC(=C1)NC(=O)C(=O)C2=C3C=CC=CN3C(=C2)CC4=CC=C(C=C4)C#N

2-[3-[(4-cyanophenyl)methyl]indolizin-1-yl]-N-(3-methyl-1,2-thiazol-5-yl)-2-oxoacetamide

1S/C22H16N4O2S/c1-14-10-20(29-25-14)24-22(28)21(27)18-12-17(26-9-3-2-4-19(18)26)11-15-5-7-16(13-23)8-6-15/h2-10,12H,11H2,1H3,(H,24,28)

IZZYUABKZYIINT-UHFFFAOYSA-N

CC1=NSC(=C1)NC(=O)C(=O)C2=C3C=CC=CN3C(=C2)CC4=CC=C(C=C4)C#N

9843935

501948-05-6

DMSO : 50 mg/mL (124.86 mM; Need ultrasonic)

1

5

5

400.099 Da

400.099 Da

116.000 Ų

29

0

669.000

0

1

4.700