RP 70676

小分子

RP 70676

R649376-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

RP 70676 is a potent inhibitor of ACAT , with IC 50 of 25 and 44 nM for rat and rabbit ACAT . In Vitro RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC 50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC 50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC 50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC 50 of 540 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)

RP 70676 是一种强效的 ACAT 抑制剂，对大鼠和家兔 ACAT 的 IC 50 分别为 25 和 44 nM。

136609-26-2

C25H28N4S

416.58 g/mol

9844830

CC1=CC(=NN1CCCCCSC2=NC(=C(N2)C3=CC=CC=C3)C4=CC=CC=C4)C

1-[5-[(4,5-diphenyl-1H-imidazol-2-yl)sulfanyl]pentyl]-3,5-dimethylpyrazole

1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27)

UUPITLNVYVCTFW-UHFFFAOYSA-N

CC1=CC(=NN1CCCCCSC2=NC(=C(N2)C3=CC=CC=C3)C4=CC=CC=C4)C

9844830

DMSO : 125 mg/mL (300.06 mM; Need ultrasonic)

1

3

9

416.203 Da

416.203 Da

71.800 Ų

30

0

492

0

1

6