RAD51-IN-1

小分子

RAD51-IN-1

R649900-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

RAD51-IN-1, a derivative of B02, is a potent inhibitor of RAD51. RAD51-IN-1 can be used for cancer research. In Vitro RAD51 is a vital component of the homologous recombination DNA repair pathway and is overexpressed in drug-resistant cancers, including aggressive triple-negative breast cancer (TNBC). RAD51-IN-1 (10 μM) decreases the ratio of RAD51 positive cells/cH2AX positive cells in MDA-MB-231 cell exposure to 6 Gy irradiation. RAD51-IN-1 (10 μM) significantly inhibits DNA damage induced RAD51 foci formation with 6 Gy irradiation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

RAD51-IN-1 是 xa0B02 的衍生物，是一种强效的 RAD51 抑制剂。RAD51-IN-1 可用于癌症研究。

2101739-18-6

C22H16ClN3O

373.8 g/mol

53245568

C1=CC=C2C(=C1)C(=O)N(C(=N2)/C=C/C3=CN=CC=C3)CC4=CC=C(C=C4)Cl

3-[(4-chlorophenyl)methyl]-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one

1S/C22H16ClN3O/c23-18-10-7-17(8-11-18)15-26-21(12-9-16-4-3-13-24-14-16)25-20-6-2-1-5-19(20)22(26)27/h1-14H,15H2/b12-9+

AQNDWTVLZSMOQU-FMIVXFBMSA-N

C1=CC=C2C(=C1)C(=O)N(C(=N2)C=CC3=CN=CC=C3)CC4=CC=C(C=C4)Cl

53245568

DMSO : 62.5 mg/mL (167.19 mM; Need ultrasonic)

0

3

4

373.098 Da

373.098 Da

45.600 Ų

27

0

582

0

1

4