RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor ( pK i =9.04) In Vitro RIP1 kinase inhibitor 1 (compound 22) strongly suppresses necroptotic cell death and phosphorylation of MLKL(pMLKL) in human colorectal adenocarcinoma HT-29 cells (nectoptosis, IC 50 =2 nM; pMLKL, IC 50 =1.3 nM) as well as mouse L-cells NCTC 929 (nectoptosis, IC 50 =15 nM; pMLKL, IC 50 =2.7 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:pKi: 9.04 (RIP1 kinase)