Rasarfin

拉沙芬

Rasarfin

R656426-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

Rasarfin is a dual Ras and ARF6 inhibitor. In Vitro Rasarfin potently inhibits agonist-induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR, as well as prevents cancer cell proliferation. ?\nRasarfin blocks GPCR internalization through inhibition of ARF6. ?\nRasarfin treatment results in a dose-dependent reduction in MDA-MB-231 cells. ?\nRasarfin inhibits the recruitment of the clathrin adaptor AP-2 to β-arrestin2 and receptor internalization, both processes that require active ARF6. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rasarfin 是一种 Ras 和 ARF6 双重抑制剂。

674359-73-0(DMSO)

C23H24ClN3O3

425.91 g/mol

O=C(C1=CC2=C(C=CC=C2)O1)NC3=CC=C(N4CCN(CC4)C(C(C)C)=O)C(Cl)=C3