ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A 2 (sPLA 2 s) with an IC 50 of 80 nM, specially targeting hGX . ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38 . Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca 2+ -dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases Form:Solid IC50& Target:80 nM (hGX)