Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK , disrupts the binding of FAK and p53. In Vitro Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53 +/+ but not in HCT116 p53 -/- xenografts in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid