MRT-83 (hydrochloride) is the potent antagonist of Smoothened ( Smo ) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo . MRT-83 (hydrochloride) has the potential for researching cancer disease In Vitro MRT-83 (hydrochloride) (compound 86) has IC 50 s of 15 and 11 nM respectively in Shh-light2 and C3H10T1/2 cells in the biological activity assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Smo