AA147 是一种小分子内质网 (ER) 蛋白稳态调节剂，选择性激活未折叠蛋白反应 (UPR) 的 ATF6 臂。 Product description AA147 is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins that regulate ATF6 activity.