BAY 61-3606 (Syk inhibitor IV) 是一种具有活性的，ATP 竞争性的可逆选择性Syk 抑制剂。它作用于乳腺癌细胞，通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡。它降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化，也降低 K-rn 细胞裂解物中 Syk 磷酸化 BAY 61-3606 (Syk inhibitor IV) is an active, ATP-competitive reversible selective Syk inhibitor. It acts on breast cancer cells and promotes TRAIL-induced apoptosis by down-regulating Mcl-1. It reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells, as well as Syk phosphorylation in K-rn cell lysates