GNF351 是一种 aryl hydrocarbon receptor (AHR) 的有效拮抗剂。GNF351 可直接与AHR​​配体结合袋相互作用，并与特征明确的光亲和性AHR配体竞争结合AHR，对应的IC50值为62 nM。 Information GNF351 GNF351 is a potent antagonist of aryl hydrocarbon receptor (AHR) . GNF351 interacts directly with the AHR ligand binding pocket and competes with a well-characterized photoaffinity AHR ligand for binding to the AHR with IC50 of 62 nM. Targets AhR (Cell-free assay) 62 nM