盐酸美呋哌瑞是一种底物竞争性和选择性的 PARP1/2 抑制剂，IC50 分别为 3.2 nM 和 1.9 nM。盐酸美呋哌瑞诱导细胞凋亡 (apoptosis)，并在体内外具有显着的抗癌活性。 Mefuparib hydrochloride is a substrate-competitive and selective PARP1/2 inhibitor with IC50s of 3.2 nM and 1.9 nM, respectively. Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo.