SHP836 is a SHP2 allosteric inhibitor, with an IC 50 of 12 μM for the full length SHP2 In Vitro SHP836 stabilizes the active conformation of SHP2, in which the catalytic site is blocked and no longer accessible to substrate. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 12 μM (SHP2)