SIRT-IN-3

小分子

2-Phenylaminobenzamide | 2-phenylamino-benzamide | AMD-11070 | MFCD02179096 | Benzamide, 2-(phenylamino)- | Z135897260 | MFCD00476529 | SCHEMBL1318994 | Benzamide, o-anilino- | BRD-K79647146-001-01-2 | EN300-7414302 | BAA21119 | HY-133998 | KUC112561N | S

SIRT-IN-3

S647474-10mg

10mg

≥99%

避光,-80℃储存

超低温冰袋运输

SIRT-IN-3 is a potent SIRT inhibitor, with an IC 50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3 , respectively (IC 50 of 74 μM and 235 μM for SIRT2 and SIRT3 , respectively). In Vitro SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

SIRT-IN-3 是一种强效的 SIRT 抑制剂，对 SIRT1 的 IC 50 为 17 μM。SIRT-IN-3 对 SIRT1 的选择性分别是 SIRT2 和 SIRT3 的 4 倍和 14 倍（对 SIRT2 和 SIRT3 的 IC 50 分别为 74 μM 和 235 μM）。

1211-19-4

C13H12N2O

212.25 g/mol

96455

C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N

2-anilinobenzamide

1S/C13H12N2O/c14-13(16)11-8-4-5-9-12(11)15-10-6-2-1-3-7-10/h1-9,15H,(H2,14,16)

JKWQUMKCVDUICQ-UHFFFAOYSA-N

C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N

96455

DMSO : 250 mg/mL (1177.86 mM; Need ultrasonic)

2

2

3

212.095 Da

212.095 Da

55.100 Ų

16

0

236

0

1

3.7