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名称
SSTC3
英文名称
SSTC3
货号
S648238-5mg
包装规格
5mg
浓度
≥98%
储存温度
-20°C储存
运输条件
超低温冰袋运输
产品介绍
SSTC3 is a casein kinase 1α (CK1α) activator ( K d = 32 nM) that inhibits WNT signaling ( EC 50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors. In Vitro SSTC3 (0-1μM, 5 days) decreases the viability of HCT116 cells in an on-target manner. This capacity is significantly reduced when the mutant CTNNB1 allele driving its carcinogenic properties is deleted. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Colorectal cancer (CRC) cell lines. Concentration: 0-1 μM. Incubation Time: 5 days. Result: Decreased the viability. Western Blot AnalysisCell Line: SW403 cells. Concentration: 100 nM. Incubation Time: 15 min. Result: Increased β-catenin phosphate levels. In Vivo SSTC3 can be maintained for 24 hours after treatment . SSTC3 (25 mg/kg, ip once daily for 8-12 days) suppresses the growth of colorectal carcinoma in CD-1 mice . SSTC3 (10 mg/kg, ip once daily for 1 month) inhibits the growth of Apc mutation-driven tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Five-week-old Apc min mice . Dosage: 10 mg/kg. Administration: IP for 1 month. Result: Inhibited the growth of Apc mutation-driven tumors. Animal Model: CD-1 mice. Dosage: 25 mg/kg. Administration: IP once daily for 8-12 days. Result: Inhibited the growth of HCT116 xenografts. Attenuated the growth of this metastatic CRC PDX and markedly reduced the cell density of residual cancer. Reduced the expression of WNT biomarkers in this CRC PDX. Form:Solid
生化机理
SSTC3 是一种酪蛋白激酶 1α (CK1α) 激活剂（K d = 32 nM），可抑制 WNT 信号转导（EC 50 = 30 nM）。与其他类别的 WNT 抑制剂相比，SSTC3 的胃肠道毒性极小。
CAS号
1242422-09-8
分子式
C23H17F3N4O3S2
分子量
518.53 g/mol
PubChem编号
46912682
Isomeric SMILES
CN(C1=CC=C(C=C1)C(F)(F)F)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3=NC(=CS3)C4=CC=CC=N4
IIUPAC Name
4-[methyl-[4-(trifluoromethyl)phenyl]sulfamoyl]-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)benzamide
INCHI
1S/C23H17F3N4O3S2/c1-30(17-9-7-16(8-10-17)23(24,25)26)35(32,33)18-11-5-15(6-12-18)21(31)29-22-28-20(14-34-22)19-4-2-3-13-27-19/h2-14H,1H3,(H,28,29,31)
InChi Key
HSFAATUFWDDUGW-UHFFFAOYSA-N
Smiles
CN(C1=CC=C(C=C1)C(F)(F)F)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3=NC(=CS3)C4=CC=CC=N4
PubChem CID
46912682
MeSH Entry Terms
4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl) benzoic acid;SSTC3
溶解性
DMSO : 125 mg/mL (241.07 mM; Need ultrasonic)
氢键供体数Hydrogen Bond Donor Count
1
氢键受体数Hydrogen Bond Acceptor Count
10
可旋转键计数Rotatable Bond Count
6
精确质量Exact Mass
518.069 Da
单同位素质量Monoisotopic Mass
518.069 Da
拓扑极表面积Topological Polar Surface Area
129.000 Ų
重原子数Heavy Atom Count
35
形式电荷Formal Charge
0
复杂度Complexity
823.000
同位素原子数Isotope Atom Count
0
共价键合单元计数Covalently-Bonded Unit Count
1
XLogP3
4.300
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SSTC3 5mg
品牌：阿拉丁
货号：S648238-5mg
级别： ≥98%
货期：30天
已售 116 件
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