S119-8

S119-8

S648606-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

S119-8 is a broad spectrum inhibitor of influenza A and B viruses, showing activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV) In Vitro S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improved calculated physical properties, while maintaining significant potency (IC 50 =1.43 μM) at non-toxic (CC 50 =66.10 μM) concentrations, albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV). S119-8 has increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. S119-8 inhibits influenza viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC 50 of 6.05 μM. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC 50 of 8.42 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Influenza A and B

S119-8 是一种广谱的甲型和乙型流感病毒抑制剂，对多种乙型流感病毒和一种耐奥司他韦的甲型流感病毒有活性，但对非流感病毒--水泡性口炎病毒（VSV）没有抑制作用。

443639-96-1

C23H24N2O

344.45 g/mol

1787280

CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)NC3=CC=CC=C3

N-(4-anilinophenyl)-4-tert-butylbenzamide

1S/C23H24N2O/c1-23(2,3)18-11-9-17(10-12-18)22(26)25-21-15-13-20(14-16-21)24-19-7-5-4-6-8-19/h4-16,24H,1-3H3,(H,25,26)

NEPKMQDGCTXOPG-UHFFFAOYSA-N

CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)NC3=CC=CC=C3

1787280

DMSO : ≥ 150 mg/mL (435.48 mM)

2

2

5

344.189 Da

344.189 Da

41.100 Ų

26

0

434

0

1

5.8