SW157765

SW157765

S648694-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs. In Vitro SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

SW157765 是一种选择性非典范葡萄糖转运体 GLUT8 (SLC2A8) 抑制剂。KRAS/KEAP1 双突变 NSCLC 细胞对 SW157765 有选择性的敏感性，这是由于 KRAS 和 NRF2 对代谢和异种生物的双重调节产生了趋同的结果。

332063-87-3

C19H13N3O3

331.32 g/mol

782267

C1=COC(=C1)/C=C/C(=O)NC2=CC3=C(C=C2)OC(=N3)C4=CC=NC=C4

(E)-3-(furan-2-yl)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)prop-2-enamide

1S/C19H13N3O3/c23-18(6-4-15-2-1-11-24-15)21-14-3-5-17-16(12-14)22-19(25-17)13-7-9-20-10-8-13/h1-12H,(H,21,23)/b6-4+

QSSYRORXXFTVFI-GQCTYLIASA-N

C1=COC(=C1)C=CC(=O)NC2=CC3=C(C=C2)OC(=N3)C4=CC=NC=C4

782267

DMSO : 25 mg/mL (75.46 mM; ultrasonic and warming and heat to 60°C)

1

5

4

331.096 Da

331.096 Da

81.200 Ų

25

0

492

0

1

2.7